| Applications of microwave-assisted organic synthesis on the multigram scale. | |
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MedLine Citation:
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PMID: 16312146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review presents a summary of reactions performed using microwave irradiation on a multigram scale. Results are described in the context of existing equipment, and equipment currently in development, for the processing of multigram to kilogram quantities of materials including single- and multimode microwave reactors and batch, batch-flow and continuous-flow systems. Although limited in number, reports found in the literature to date suggest that with appropriate controls, reproducible scale-up of microwave reactions is feasible and requires minimal re-optimization of laboratory-scale reaction conditions. This feature, along with the dramatic reductions in reaction time generally observed for microwave reactions suggests that application of this technology in process research could be beneficial. |
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Authors:
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Scott E Wolkenberg; William D Shipe; Craig W Lindsley; James P Guare; Joseph M Pawluczyk |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in drug discovery & development Volume: 8 ISSN: 1367-6733 ISO Abbreviation: Curr Opin Drug Discov Devel Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-29 Completed Date: 2006-11-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887519 Medline TA: Curr Opin Drug Discov Devel Country: England |
Other Details:
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Languages: eng Pagination: 701-8 Citation Subset: IM |
Affiliation:
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Merck & Co Inc, Technology Enabled Synthesis Group, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA. scott_wolkenberg@merck.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzopyrans
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chemical synthesis Combinatorial Chemistry Techniques Dioxolanes / chemical synthesis Microwaves* Organic Chemicals / chemical synthesis* Quinazolines / chemical synthesis Temperature Thiocarbamates / chemical synthesis Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Benzopyrans; 0/Dioxolanes; 0/Organic Chemicals; 0/Quinazolines; 0/Thiocarbamates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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