Document Detail


Applications of microfluidics for molecular diagnostics.
MedLine Citation:
PMID:  23329451     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Diagnostic assays implemented in microfluidic devices have developed rapidly over the past decade and are expected to become commonplace in the next few years. Hundreds of microfluidics-based approaches towards clinical diagnostics and pathogen detection have been reported with a general theme of rapid and customizable assays that are potentially cost-effective. This chapter reviews microfluidics in molecular diagnostics based on application areas with a concise review of microfluidics in general. Basic principles of microfabrication are briefly reviewed and the transition to polymer fabricated devices is discussed. Most current microfluidic diagnostic devices are designed to target a single disease, such as a given cancer or a variety of pathogens, and there will likely be a large market for these focused devices; however, the future of molecular diagnostics lies in highly multiplexed microfluidic devices that can screen for potentially hundreds of diseases simultaneously.
Authors:
Harikrishnan Jayamohan; Himanshu J Sant; Bruce K Gale
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  949     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  305-34     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, State of Utah Center of Excellence for Biomedical Microfluidics, University of Utah, Salt Lake City, UT, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The application of microfluidic devices for viral diagnosis in developing countries.
Next Document:  Quantitative heterogeneous immunoassays in protein modified polydimethylsiloxane microfluidic channe...