Document Detail


Applications of β-limit Dextrin as a Matrix Forming Excipient for Fast Disintegrating Buccal Dosage Formats.
MedLine Citation:
PMID:  23331905     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT - Purpose. To compare the properties of buccal delivery matrices (wafers) made with dextrin, β-limit dextrin and pre-gelatinised starch. Methods. The constituent α-glucans were tested for their mucoadhesive properties in solution plus their content of crystalline material (differential scanning calorimetry, DSC). Wafers were made by lyophilisation of aqueous solutions/dispersions of the α-glucans. Physical properties of the wafers were evaluated using texture analysis, dissolution coupled to photography and scanning electron microscopy (SEM). Results. The results highlighted how the β-limit dextrins chemical and physical properties were ideally suited for the production of buccal delivery wafers. Dissolution testing confirmed the excellent hydration profile of the β-limit dextrin (within wafers) with time. Using SEM it was evident that the homogeneous "bee-hive" like structure of the β-limit dextrin wafers, unlike the other α-glucans, provided a rapidly hydratable strong porous matrix. Conclusions. The β-limit dextrin α-glucan makes a superb (lyophilised) mucoadhesive delivery structure for the delivery of active agents to the buccal mucosa. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
Authors:
Xin Qi; Richard Tester; Yu Liu; Margaret Mullin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques     Volume:  15     ISSN:  1482-1826     ISO Abbreviation:  J Pharm Pharm Sci     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807281     Medline TA:  J Pharm Pharm Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  669-79     Citation Subset:  IM    
Affiliation:
Glycologic Limited, 70 Cowcaddens Road, Glasgow, UK.
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