| Applications of β-limit Dextrin as a Matrix Forming Excipient for Fast Disintegrating Buccal Dosage Formats. | |
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MedLine Citation:
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PMID: 23331905 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT - Purpose. To compare the properties of buccal delivery matrices (wafers) made with dextrin, β-limit dextrin and pre-gelatinised starch. Methods. The constituent α-glucans were tested for their mucoadhesive properties in solution plus their content of crystalline material (differential scanning calorimetry, DSC). Wafers were made by lyophilisation of aqueous solutions/dispersions of the α-glucans. Physical properties of the wafers were evaluated using texture analysis, dissolution coupled to photography and scanning electron microscopy (SEM). Results. The results highlighted how the β-limit dextrins chemical and physical properties were ideally suited for the production of buccal delivery wafers. Dissolution testing confirmed the excellent hydration profile of the β-limit dextrin (within wafers) with time. Using SEM it was evident that the homogeneous "bee-hive" like structure of the β-limit dextrin wafers, unlike the other α-glucans, provided a rapidly hydratable strong porous matrix. Conclusions. The β-limit dextrin α-glucan makes a superb (lyophilised) mucoadhesive delivery structure for the delivery of active agents to the buccal mucosa. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. |
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Authors:
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Xin Qi; Richard Tester; Yu Liu; Margaret Mullin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques Volume: 15 ISSN: 1482-1826 ISO Abbreviation: J Pharm Pharm Sci Publication Date: 2013 Dec |
Date Detail:
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Created Date: 2013-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9807281 Medline TA: J Pharm Pharm Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 669-79 Citation Subset: IM |
Affiliation:
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Glycologic Limited, 70 Cowcaddens Road, Glasgow, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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