Document Detail

Applications of flow cytometry in diagnostic pathology.
MedLine Citation:
PMID:  2648806     Owner:  NLM     Status:  MEDLINE    
The growth of flow cytometry in diagnostic pathology has been aided by the development of instruments that can be incorporated into the pathology laboratory and new assays that have expanded the role of flow cytometry in clinical medicine. The evaluation of DNA content in solid tumors is rapidly becoming a routine procedure in surgical pathology; this topic is only briefly covered here and has been more completely reviewed elsewhere. Other assays are more completely discussed, including reticulocyte analysis, identification of antiplatelet and antineutrophil antibodies in immune cytopenias, and lymphocyte antibodies in organ transplant cross-matching. Mitogen cell cycle analysis, detection of nuclear antigens, and neutrophil function assays are also briefly covered. This review is intended to increase the awareness of how flow cytometry can be incorporated into the clinical pathology laboratory, beyond its traditional use in monoclonal antibody immunophenotyping.
C A Hanson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  91     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-09     Completed Date:  1989-05-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S27-31     Citation Subset:  AIM; IM    
Department of Pathology, University of Michigan, Medical School, Ann Arbor.
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MeSH Terms
Antibodies / analysis
Antibodies, Antinuclear / analysis
Blood Platelets / immunology
Cell Count
Cell Nucleus / analysis
DNA / analysis
Flow Cytometry*
Lymphocytes / immunology
Neutrophils / immunology
Pathology / methods*
Reticulocytes / cytology
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Antinuclear; 9007-49-2/DNA

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