| Applications of extracorporeal photochemotherapy in "non-oncological" diseases. | |
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MedLine Citation:
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PMID: 7912229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Photopheresis (ECP) is a new therapy for oncological and autoimmune diseases consisting in the reinfusion of 3-9 x 10(9) leukocytes, taken from the patient by leukapheresis, and treated in an extracorporeal system with 8-methoxypsoralen and ultraviolet light A. Nine patients affected by T cell immunomediated diseases (2 scleroderma, 1 chronic GVHD, 1 polyarteritis, 1 rheumatoid arthritis and 4 heart transplant patients with numerous episodes of acute rejection) were treated with ECP. Photopheresis was performed on 2 consecutive days every 3-4 weeks. All patients affected by autoimmune diseases experienced an improvement during treatment with ECP. In 2 of the 4 patients with heart transplant, rejection was reversed by photopheresis. No major side effects were observed during the treatment. In conclusion ECP is a safe and well tolerated therapy. Although the number of patients is small, ECP seems to be an effective modality in many diseases. |
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Authors:
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R Dall'Amico; F Zulian; G Montini; B Andretta; L Murer; F Rossetti; U Livi; G Zacchello; F Zacchello |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of artificial organs Volume: 16 Suppl 5 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-07-25 Completed Date: 1994-07-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: ITALY |
Other Details:
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Languages: eng Pagination: 168-72 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arthritis, Rheumatoid / drug therapy Child Female Graft Rejection / drug therapy Graft vs Host Disease / drug therapy Heart Transplantation Humans Leukapheresis Male Middle Aged Photopheresis* Polyarteritis Nodosa / drug therapy Scleroderma, Systemic / drug therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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