Document Detail

Applications of TMS to therapy in psychiatry.
MedLine Citation:
PMID:  12436089     Owner:  NLM     Status:  MEDLINE    
Transcranial magnetic stimulation (TMS) has been applied to a growing number of psychiatric disorders as a noninvasive probe to study the underlying neurobiologic processes involved in psychiatric disorders and as a putative treatment. Transcranial magnetic stimulation is unparalleled in its ability to test the hypotheses generated by functional neuroimaging studies by modulating activity in selected neural circuits. As a focal intervention that may in some cases exert lasting effects, TMS offers the hope of targeting and ameliorating the circuitry underlying psychiatric disorders. The ultimate success of such an approach depends on our knowledge of the neural circuitry underlying these disorders, of how TMS exerts its effects, and of how to control the application of TMS to exert the desired effects. Although most clinical trials have focused on the treatment of major depression, increasing attention has been paid to schizophrenia and anxiety disorders. Many of these trials have supported a significant effect of TMS, but in some studies the effect is small and short lived. Current challenges in the field include determining how to enhance the efficacy of TMS in these disorders and how to identify patients for whom TMS may be efficacious.
Sarah H Lisanby; Leann H Kinnunen; Michael J Crupain
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  19     ISSN:  0736-0258     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-11-18     Completed Date:  2003-01-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  344-60     Citation Subset:  IM    
Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York 10032, USA.
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MeSH Terms
Anxiety Disorders / physiopathology,  therapy*
Bipolar Disorder / therapy
Brain / physiopathology*
Clinical Trials as Topic
Cognition Disorders / therapy
Cross-Over Studies
Depressive Disorder, Major / physiopathology,  therapy*
Electric Stimulation / methods*
Electroconvulsive Therapy / methods
Equipment Safety
Magnetics / therapeutic use*
Meta-Analysis as Topic
Placebo Effect
Schizophrenia / physiopathology,  therapy*
Treatment Outcome
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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