Document Detail


Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistry.
MedLine Citation:
PMID:  21971646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxygenation and desaturation reactions are inherently associated with the abstraction of a hydrogen from the fatty acid substrate. Since the first published application in 1965, stereospecific placement of a labeled hydrogen isotope (deuterium or tritium) at the reacting carbons has proven a highly effective strategy for investigating the chemical mechanisms catalyzed by lipoxygenases, hemoprotein fatty acid dioxygenases including cyclooxygenases, cytochromes P450, and also the desaturases and isomerases. This review presents a synopsis of all published studies through 2010 on the synthesis and use of stereospecifically labeled fatty acids (71 references), and highlights some of the mechanistic insights gained by application of stereospecifically labeled fatty acids.
Authors:
Alan R Brash; Claus Schneider; Mats Hamberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-10-05
Journal Detail:
Title:  Lipids     Volume:  47     ISSN:  1558-9307     ISO Abbreviation:  Lipids     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-25     Completed Date:  2013-01-24     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  101-16     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. alan.brash@vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acid Desaturases / metabolism*
Fatty Acids / metabolism*
Humans
Kinetics
Oxygenases / metabolism*
Prostaglandin-Endoperoxide Synthases / metabolism
Grant Support
ID/Acronym/Agency:
GM-015431/GM/NIGMS NIH HHS; GM-074888/GM/NIGMS NIH HHS; GM-076592/GM/NIGMS NIH HHS; P01 GM015431-44/GM/NIGMS NIH HHS; R01 GM074888/GM/NIGMS NIH HHS; R01 GM074888-07/GM/NIGMS NIH HHS; R01 GM076592-05/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; EC 1.13.-/Oxygenases; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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