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Applications of Nanosystems to Anticancer Drug Therapy (Part II. Dendrimers, Micelles, Lipid-based Nanosystems).
MedLine Citation:
PMID:  23578193     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The great efforts of many researchers have brought down some of the barriers that exist to turn a good in vitro compound into a potential in vivo drug. The advent of pharmaceutical nanotechnology has allowed an arsenal of drugs with poor stability, low solubility, high off-target toxicity and other disadvantageous features, to be accessible as pharmaceutical products that could be administered to a patient. Nanotechnology was introduced in drug delivery very long ago, but has flourished with unprecedented intensity during the last twenty years and now a diversity of nano-based preparations are at clinical stage of development or already available in the market. Undoubtedly, nanotechnology plays a key role in future pharmaceutical development and pharmacotherapy. In the first part of this review we have already discussed recent (2008-2012) patents on linear polymer-based nanosystems (nanogels, nanospheres and nanocapsules) applications to cancer therapy. Here we have expanded such analysis to branched polymers (dendrimers), self-assembling nanomicelles and lipid-based nanocarriers.
Authors:
María E Ruiz; Melisa E Gantner; Alan Talevi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-10
Journal Detail:
Title:  Recent patents on anti-cancer drug discovery     Volume:  -     ISSN:  2212-3970     ISO Abbreviation:  Recent Pat Anticancer Drug Discov     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266081     Medline TA:  Recent Pat Anticancer Drug Discov     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Biopharmacy, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata (UNLP)-Argentinean National Council for Scientific and Technical Research (CONICET) CCT La Plata. 47 and 115, La Plata (B1900AJI), Buenos Aires, Argentina. atalevi@biol.unlp.edu.ar;alantalevi@gmail.com.
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