Document Detail


Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment.
MedLine Citation:
PMID:  23507088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of applications in medicine, including scaffolding for tissue engineering, dermatological fillers and viscosupplementation for osteoarthritis treatment. HA is available in most connective tissues in body fluids such as synovial fluid and the vitreous humor of the eye. HA is responsible for several structural properties of tissues as a component of extracellular matrix and is involved in cellular signaling. Degradation of HA is a stepwise process that can occur via enzymatic or non-enzymatic reactions. A reduction in HA mass or molecular weight via degradation or slowing of synthesis affects physical and chemical properties such as tissue volume, viscosity and elasticity. This review addresses the distribution, turnover and tissue-specific properties of HA. This information is used as the context for considering recent products and strategies for modifying the viscoelastic properties of HA in tissue engineering, as a dermal filler and in osteoarthritis treatment.
Authors:
A Fakhari; C Berkland
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-03-15
Journal Detail:
Title:  Acta biomaterialia     Volume:  9     ISSN:  1878-7568     ISO Abbreviation:  Acta Biomater     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-05-31     Completed Date:  2013-10-17     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  England    
Other Details:
Languages:  eng     Pagination:  7081-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Cosmetic Techniques / trends*
Cosmetics / administration & dosage
Dermatologic Agents / administration & dosage
Humans
Hyaluronic Acid / administration & dosage*,  chemical synthesis*
Injections, Intra-Articular
Injections, Intradermal
Osteoarthritis / drug therapy*
Rejuvenation
Rheumatology / trends*
Skin Aging / drug effects*
Tissue Engineering / trends*
Viscosupplementation
Grant Support
ID/Acronym/Agency:
R01 DE022472/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Cosmetics; 0/Dermatologic Agents; 9004-61-9/Hyaluronic Acid
Comments/Corrections

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