Document Detail


Application of whole-organ tissue engineering in hepatology.
MedLine Citation:
PMID:  22890112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Initially hailed as the ultimate solution to organ failure, engineering of vascularized tissues such as the liver has stalled because of the need for a well-structured circulatory system that can maintain the cells seeded inside the construct. A new approach has evolved to overcome this obstacle. Whole-organ decellularization is a method that retains most of the native vascular structures of the organ, providing microcirculatory support and structure, which can be anastomosed with the recipient circulation. The technique was first applied to the heart and then adapted for the liver. Several studies have shown that cells can be eliminated, the extracellular matrix and vasculature are reasonably preserved and, after repopulation with hepatocytes, these grafts can perform hepatic functions in vitro and in vivo. Progress is rapidly being made as researchers are addressing several key challenges to whole-organ tissue engineering, such as ensuring correct cell distribution, nonparenchymal cell seeding, blood compatibility, immunological concerns, and the source of cells and matrices.
Authors:
Basak E Uygun; Martin L Yarmush; Korkut Uygun
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-14
Journal Detail:
Title:  Nature reviews. Gastroenterology & hepatology     Volume:  9     ISSN:  1759-5053     ISO Abbreviation:  Nat Rev Gastroenterol Hepatol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-05-21     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  101500079     Medline TA:  Nat Rev Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  738-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Extracellular Matrix / pathology
Gastroenterology / trends*
Hepatocytes / pathology,  transplantation
Liver / blood supply,  pathology
Liver Failure / pathology,  therapy*
Mice
Microcirculation
Tissue Engineering / trends*
Grant Support
ID/Acronym/Agency:
K99 DK088962/DK/NIDDK NIH HHS; K99DK088962/DK/NIDDK NIH HHS; R01 DK084053/DK/NIDDK NIH HHS; R01DK084053/DK/NIDDK NIH HHS; R01DK096075R01/DK/NIDDK NIH HHS
Comments/Corrections

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