| Application of an untargeted metabolomics approach for the identification of compounds that may be responsible for observed differential effects in chickens fed an organic and a conventional diet. | |
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MedLine Citation:
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PMID: 22220906 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to apply an untargeted NMR and LC-MS-based metabolomics approach to detect potential differences between an organically and a conventionally produced feed, which caused statistically significant differences in growth, in the response to an immunological challenge and in the gene expression profiles in the small intestine of laying hens. A fractionation procedure was set up to create multiple fractions of the feed, which were subsequently analysed by NMR and UPLC-TOF/MS operating in positive mode. Comparison of the profiles revealed that the most apparent differences came from the isoflavones in the soy as well as a compound with a molecular mass of 441.202 (M + 1)(+), which was identified as N,N'-diferuloylputrescine (DFP) and came from the corn. Whether the observed differences in effects are due to the higher levels of isoflavones and DFP is unclear, as is the fact whether the observed differences are typical for organic or conventional produced corn and soy. However, this study shows that this metabolomics approach is suitable for detecting potential differences between products, even in levels of compounds that would have been overlooked with a more targeted approach. As such, the method is suitable for a more systematic study on differences between conventionally and organically produced food. |
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Authors:
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A Ruiz-Aracama; A Lommen; M Huber; L Van De Vijver; R Hoogenboom |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-21 |
Journal Detail:
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Title: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Volume: - ISSN: 1944-0057 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485040 Medline TA: Food Addit Contam Part A Chem Anal Control Expo Risk Assess Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a RIKILT - Institute of Food Safety , PO Box 230 , NL-6700 AE Wageningen , the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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