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Application of transretinal current stimulation for the study of bipolar-amacrine transmission.
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MedLine Citation:
PMID:  6151585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transretinal current flowing from the receptor side to the vitreous side depolarizes the axon terminals of retinal cells and facilitates the release of transmitter. Such current elicited a depolarizing response in off-center bipolar cells and a hyperpolarizing response in on-center bipolar cells. It also elicited a response of relatively complex waveform in amacrine cells. The responses elicited in bipolar cells were suppressed in the presence of 5-10 mM glutamate in the perfusing Ringer solution, while the responses of amacrine cells persisted, although their waveform changed to a simple one that showed monotonic depolarization irrespective of the type of amacrine cell and were accompanied by a decrease in the membrane resistance. The results indicate excitatory synaptic transmission from bipolar cells to amacrine cells. Since the response elicited by current in ON-OFF cells was almost identical to those elicited in ON or OFF amacrine cells, the transient nature of their light response cannot be due to their membrane properties. ON-OFF cells responded to transretinal current flowing in the opposite direction with a small hyperpolarization accompanied by a resistance increase. The hyperpolarizing response was suppressed by the addition of GABA in glutamate Ringer solution. The results suggest an activation by the current of GABA-ergic feedback pathways from amacrine cells to bipolar cells.
Authors:
J Toyoda; M Fujimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of general physiology     Volume:  84     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-03-08     Completed Date:  1985-03-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  915-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carps
Electric Stimulation
Evoked Potentials / drug effects
Glutamates / pharmacology
Glutamic Acid
Membrane Potentials / drug effects
Microelectrodes
Neurons / physiology*
Photic Stimulation
Photoreceptor Cells / physiology
Retina / physiology*
Synapses / physiology
Synaptic Transmission* / drug effects
Grant Support
ID/Acronym/Agency:
EY 02392/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Glutamates; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 12 Year: 1984
Volume: 84 Issue: 6
First Page: 915 Last Page: 925
ID: 2228769
Publisher Id: 85107065
PubMed Id: 6151585

Application of transretinal current stimulation for the study of bipolar-amacrine transmission


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