Document Detail


Application of the threshold of toxicological concern approach to ingredients in personal and household care products.
MedLine Citation:
PMID:  16213074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the absence of chemical-specific data, the threshold of toxicological concern (TTC) provides a method to determine a conservative estimate of a chronic oral exposure below which there is a very low probability of risk. The TTC approach was originally developed to support exposures to indirect food additives and was based on linear low-dose risk estimates to assure protection in the event that the chemical was later determined to be a carcinogen. Subsequently, TTC values based on noncancer endpoints were proposed for chemicals without structural alerts for genotoxicity. The original database supporting the TTC values for noncancer endpoints includes >600 structurally diverse chemicals. The objectives of this work were to evaluate the applicability of the TTC database to ingredients used in consumer products based on a comparison of the diversity of chemical structures with those in the original TTC database and to confirm that the range of NOELs for these ingredients is consistent with the range of NOELs in the original database. The results show good coverage of the product ingredient structures and confirm that the NOELs for the ingredient chemicals are similar in range to the original dataset, supporting the use of the TTC for ingredients in consumer products.
Authors:
Karen Blackburn; Julie A Stickney; Heather L Carlson-Lynch; Patricia M McGinnis; Lara Chappell; Susan P Felter
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Publication Detail:
Type:  Journal Article     Date:  2005-10-04
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  43     ISSN:  0273-2300     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-15     Completed Date:  2006-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-59     Citation Subset:  IM    
Affiliation:
Procter and Gamble Company, 11810 E. Miami River Road, Cincinnati, OH 45253, USA. blackburn.kl@pg.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogenicity Tests
Databases, Factual
Detergents / chemistry,  toxicity*
Household Products / analysis,  toxicity*
Humans
Mice
Mutagenicity Tests
No-Observed-Adverse-Effect Level
Rabbits
Rats
Soaps / chemistry,  toxicity*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Detergents; 0/Soaps

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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