| Application of terahertz absorption spectroscopy to evaluation of aging variation of medicine. | |
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MedLine Citation:
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PMID: 21321447 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD(®) (5 mg), Basen OD(®) (0.2 mg) and Gaster D(®) (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents. |
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Authors:
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Masaya Kawase; Tadashi Saito; Masafumi Ogawa; Hideki Uejima; Yasutoshi Hatsuda; Sonoyo Kawanishi; Yoshihiko Hirotani; Michiaki Myotoku; Kenji Ikeda; Hiroki Konishi; Ikumi Iga; Junji Yamakawa; Seizi Nishizawa; Kohji Yamamoto; Masahiko Tani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry Volume: 27 ISSN: 1348-2246 ISO Abbreviation: Anal Sci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511078 Medline TA: Anal Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 209 Citation Subset: IM |
Affiliation:
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Nagahama Institute of Bio-science and Technology. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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