Document Detail

Application of statistical experimental designs for the optimization of medium constituents for the production of citric acid from pineapple waste.
MedLine Citation:
PMID:  17936623     Owner:  NLM     Status:  MEDLINE    
Statistical experimental designs were applied for the optimization of medium constituents for citric acid production by Yarrowia lipolytica NCIM 3589 in solid state fermentation (SSF) using pineapple waste as the sole substrate. Using Plackett-Burman design, yeast extract, moisture content of the substrate, KH(2)PO(4) and Na(2)HPO(4) were identified as significant variables which highly influenced citric acid production and these variables were subsequently optimized using a central composite design (CCD). The optimum conditions were found to be yeast extract 0.34 (%w/w), moisture content of the substrate 70.71 (%), KH(2)PO(4) 0.64 (%w/w) and Na(2)HPO(4) 0.69 (%w/w). Citric acid production at these optimum conditions was 202.35 g/kg ds (g citric acid produced/kg of dried pineapple waste as substrate).
Sarat Babu Imandi; Veera Venkata Ratnam Bandaru; Subba Rao Somalanka; Sita Ramalakshmi Bandaru; Hanumantha Rao Garapati
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Publication Detail:
Type:  Journal Article     Date:  2007-10-23
Journal Detail:
Title:  Bioresource technology     Volume:  99     ISSN:  0960-8524     ISO Abbreviation:  Bioresour. Technol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9889523     Medline TA:  Bioresour Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  4445-50     Citation Subset:  IM    
Center for Biotechnology, Department of Chemical Engineering, College of Engineering, Andhra University, Visakhapatnam 530 003, India.
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MeSH Terms
Biochemistry / methods
Biotechnology / methods*
Citric Acid / analysis,  chemistry
Culture Media
Industrial Microbiology
Models, Statistical
Research Design
Yarrowia / metabolism
Yeasts / metabolism
Reg. No./Substance:
0/Culture Media; 77-92-9/Citric Acid

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