| Application of selected topological indices to predict retention parameters of selected bile acids separated on modified TLC plates. | |
| | |
MedLine Citation:
|
PMID: 18536173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this work was to apply some topological indices to predict chromatographic separations of selected bile acids such as: cholic (C), glycocholic (GC), glycodeoxycholic (GDC), chenodeoxycholic (CDC), deoxycholic (DC), lithocholic (LC) and glycolithocholic (GLC). The bile acids were separated on various glass and aluminum TLC plates precoated with silica gel only or with mixture of silica gel and Kieselguhr mixture impregnated with aqueous solution of 1%, 2.5% and 5% of CuSO4, MnSO4, FeSO4 and NiSO4. The mixture of n-hexane - ethyl acetate -acetic acid in various volume compositions was used as a mobile phase. Experimental R(F) and R(M) values obtained on all TLC plates modified with the use of inorganic salts were compared with respective topological indices of studied bile acids. It was suggested that of all indices only index C gives good correlation with chromatographic parameters R(F) and R(M) and can be useful for prediction of chromatographic separations of studied bile acids but only for their optimal separation conditions. |
| | |
Authors:
|
Małgorzata Dołowy |
Related Documents
:
|
3082773 - Fecal bile acids and neutral sterols in rats with spontaneous colon cancer. 3807313 - Manganese-bilirubin cholestasis. further studies in pathogenesis. 7295473 - The effect of diflunisal on hyaluronic acid production by 'activated' human synovial fi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta poloniae pharmaceutica Volume: 65 ISSN: 0001-6837 ISO Abbreviation: Acta Pol Pharm Publication Date: 2008 Jan-Feb |
Date Detail:
|
Created Date: 2008-06-09 Completed Date: 2008-06-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985167R Medline TA: Acta Pol Pharm Country: Poland |
Other Details:
|
Languages: eng Pagination: 51-7 Citation Subset: IM |
Affiliation:
|
Department of Analytical Chemistry, Faculty of Pharmacy, Silesian University of Medicine, Sosnowiec, Poland. mdolowy@slam.katowice.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adsorption Bile Acids and Salts / chemistry* Chromatography, Thin Layer / methods* Quantitative Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimization and validation of capillary electrophoretic method for the analysis of amphenicols in p...
Next Document: Analysis of acid-base properties of riboflavin calculated via semi-empirical methods.