| Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients. | |
| | |
MedLine Citation:
|
PMID: 19027898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this prospective randomised clinical study was to compare the efficacy of recombinant bone morphogenetic protein 7 (rhBMP-7) and platelet-rich plasma (PRP) as bone-stimulating agents in the treatment of persistent fracture non-unions. One hundred and twenty patients were randomised into two treatment groups (group rhBMP-7 vs. group PRP). Sixty patients with sixty fracture non-unions were assigned to each group (median age: 44 years, range 19-65, for the rhBMP-7 group and 41 years, range 21-62, for the PRP group, respectively). In the rhBMP-7 group, there were 15 tibial non-unions, 10 femoral, 15 humeral, 12 ulnar, and 8 radial non-unions. In the PRP group, there were 19 tibial non-unions, 8 femoral, 16 humeral, 8 ulnar, and 9 radial non-unions. The median number of operations performed prior to our intervention was 2 (range 1-5) and 2 (range 1-5) with autologous bone graft being used in 23 and 21 cases for the rhBMP-7 and PRP groups, respectively. Both clinical and radiological union occurred in 52 (86.7%) cases of the rhBMP-7 group compared to 41 (68.3%) cases of the PRP group, with a lower median clinical and radiographic healing time observed in the rhBMP-7 group (3.5 months vs. 4 months and 8 months vs. 9 months, respectively). This study supports the view that in the treatment of persistent long bone non-unions, the application of rhBMP-7 as a bone-stimulating agent is superior compared to that of PRP with regard to their clinical and radiological efficacy. |
| | |
Authors:
|
G M Calori; L Tagliabue; L Gala; M d'Imporzano; G Peretti; W Albisetti |
Related Documents
:
|
3102188 - Indications of primary osteosynthesis in patients with fractures of long bones of extre... 3356728 - Diaphyseal fractures of the humerus. treatment with prefabricated braces. 9076298 - Ipsilateral femoral neck and shaft fractures. 3508158 - Cerclage wiring in the management of comminuted fractures of the femoral shaft. 7994188 - Normal ranges for bone loss rates. 2895448 - Computer-aided three-dimensional reconstruction and measurement of the vestibular end-o... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2008-11-22 |
Journal Detail:
|
Title: Injury Volume: 39 ISSN: 1879-0267 ISO Abbreviation: Injury Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-02 Completed Date: 2009-07-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0226040 Medline TA: Injury Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1391-402 Citation Subset: IM |
Affiliation:
|
Orthopaedic Institute, G. Pini University of Milan, Milan, Italy. gmc@studiocalori.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Bone Morphogenetic Protein 7 / therapeutic use* Female Femoral Fractures / drug therapy, surgery Fracture Healing / drug effects Fractures, Ununited / drug therapy*, surgery Humans Humeral Fractures / drug therapy, surgery Male Middle Aged Osteogenesis / drug effects* Platelet-Rich Plasma* Prospective Studies Recombinant Proteins / therapeutic use Tibial Fractures / drug therapy, surgery Ulna Fractures / drug therapy, surgery Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/BMP7 protein, human; 0/Bone Morphogenetic Protein 7; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fuzzy-model-based hybrid predictive control.
Next Document: Increasing adiposity in normal ovulatory women affects adipocytokine expression in subcutaneous and ...