Document Detail


Application of red cell distribution width to screening for coeliac disease in insulin-dependent diabetes mellitus.
MedLine Citation:
PMID:  10540781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coeliac disease has been reported to occur in 2-5 per cent of insulin-dependent diabetic patients (IDDM). Suitable non-invasive screening tests would allow identification of these patients. The aim of this study was to determine the value of the red cell distribution width (RDW) in detecting unrecognised coeliac disease in insulin-dependent diabetic patients (IDDM). All patients (n = 208) attending the Diabetic out-patient clinics at 2 adjacent centres who had a full blood picture and RDW carried out in the past 18 months were included. IDDM patients with an elevated RDW were identified and their charts were reviewed to determine if they had symptoms or laboratory abnormalities compatible with coeliac disease. They were invited to attend for serological screening. Ninety-five of 208 patients had an elevated RDW of whom 66 had non-insulin dependent diabetes mellitus and 29 had IDDM. Two of the 29 IDDM patients had died in the interim period. Six of the remaining 27 IDDM patients had previously been tested for serological markers associated with coeliac disease, of whom 1 had a positive antigliadin antibody titre (IgA-AGA 199 EU) and normal duodenal biopsy. Eighteen of the remaining 21 patients with IDDM consented to serological testing of whom only 1 had a positive titre of antiendomysial antibody (IgA-EMA) and villous atrophy. Although the RDW is known from previous studies to be a sensitive predictor for coeliac disease, this study has demonstrated its poor specificity in predicting IDDM patients who may have coeliac disease. The RDW is not recommended as a screening test for coeliac disease in patients with IDDM.
Authors:
S D Johnston; C Ritchie; J Robinson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Irish journal of medical science     Volume:  168     ISSN:  0021-1265     ISO Abbreviation:  Ir J Med Sci     Publication Date:    1999 Jul-Sep
Date Detail:
Created Date:  1999-11-10     Completed Date:  1999-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  IM    
Affiliation:
Department of Medicine, Craigavon Area Hospital, Northern Ireland. sjohnson@potblack.thegap.com
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MeSH Terms
Descriptor/Qualifier:
Celiac Disease / blood,  complications,  diagnosis*
Diabetes Mellitus, Type 1 / blood*,  complications
Erythrocyte Indices*
Female
Humans
Male
Mass Screening*
Middle Aged
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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