Document Detail


Application of a ready-to-use calcium ionophore increases rates of fertilization and pregnancy in severe male factor infertility.
MedLine Citation:
PMID:  22921909     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To analyze whether a ready-to-use calcium ionophore improves outcomes, from fertilization to live birth, in patients with severe male factor infertility. DESIGN: Artificial oocyte activation offered to applicable patients over a 20-month period. SETTING: Specialized in vitro fertilization (IVF) centers in Austria and Germany. PATIENT(S): Twenty-nine azoospermic and 37 cryptozoospermic men. INTERVENTION(S): Mature oocytes treated with a ready-to-use Ca(2+)-ionophore (GM508 Cult-Active) immediately after intracytoplasmic sperm injection (ICSI). MAIN OUTCOME MEASURE(S): Rates of fertilization, implantation, clinical pregnancy, and live birth. RESULT(S): Patients had had 88 previous cycles without artificial activation that resulted in a fertilization rate of 34.7%, 79 transfers (89.8%), and 5 pregnancies, which all spontaneously aborted except one. After artificial oocyte activation, the fertilization rate was 56.9%. In terms of fertilization rate, both azoospermic (64.4%) and cryptozoospermic (48.4%) men statistically significantly benefited from use of the ionophore. In 73 transfer cycles, positive β-human chorionic gonadotropin levels was observed in 34 cases (46.6%) and 29 cycles (39.7%) that ended with a clinical pregnancy. The corresponding implantation rate was 33.3%. Four spontaneous abortions occurred (11.8%), and 32 healthy children were born. CONCLUSION(S): This is the first prospective multicenter study on artificial oocyte activation in severe male factor infertility. Present data indicate that a ready-to-use calcium ionophore can yield high fertilization and pregnancy rates for this particular subgroup. In addition to fertilization failure after ICSI, severe male factor infertility is an additional area for application of artificial oocyte activation.
Authors:
Thomas Ebner; Maria Köster; Omar Shebl; Marianne Moser; Hans Van der Ven; Gernot Tews; Markus Montag
Related Documents :
9538329 - Expression of epidermal growth factor and its receptor in equine placental tissues.
24937969 - Fertility-sparing partial hysterectomy for gestational trophoblastic neoplasia: an anal...
23095139 - Definitions of infertility and recurrent pregnancy loss: a committee opinion.
25030719 - Pregnancy and birth survey after the great east japan earthquake and fukushima daiichi ...
24974559 - Contraceptive use in adolescents in sub-saharan africa: evidence from demographic and h...
12688989 - First search for the flavor changing neutral current decay d0-->gammagamma.
22344039 - Associations of pregnancy complications with calculated cardiovascular disease risk and...
3217929 - Hla and red blood group antigens in pregnancy disorders.
10684569 - Participation of the gm1 ganglioside in the gastrulation of anuran amphibian bufo arena...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Landes- Frauen- und Kinderklinik, Kinderwunschzentrum, Linz, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sleep-related collisions in United Arab Emirates.
Next Document:  The effect of the new 2010 World Health Organization criteria for semen analyses on male infertility...