Document Detail


Application of a radioimmunoassay screening test for detection and management of phencyclidine intoxication.
MedLine Citation:
PMID:  7430414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A radioimmunoassay procedure has been developed to monitor patients suspected of phencyclidine (PCP) intoxication. Symptoms in 11 patients suspected of phencyclidine intoxication included violent, aggressive behavior with delusions, hallucinations, agitation, and other signs of toxic psychosis. In five subjects serum concentrations of PCP ranged between 0.5 and 40 ng/ml. For laboratory confirmation, ascorbic acid should be administered to the patient after collecting the initial urine specimen. The initial urine and the first and second specimen after acidification should be collected and submitted for analysis. By following this provocative mobilization procedure, phencyclidine has been identified in the first or second postacidification urine when the initial specimen gave either a negative or questionable reaction. Patients reporting to emergency rooms with hallucinations and psychosis and a history of "pot" smoking should be screened for the presence of phencyclidine in their blood and urine. For those cases that turn out to be negative for the phencyclidine group of compounds, other hallucinogenic drugs such as lysergic acid diethylamide, ketamine, mescaline, or psilocybin may be suspect.
Authors:
B Kaul; B Davidow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  20     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:    1980 Aug-Sep
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  500-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Female
Humans
Male
Phencyclidine / analysis,  blood,  poisoning*
Phencyclidine Abuse / diagnosis*,  therapy
Radioimmunoassay / methods*
Chemical
Reg. No./Substance:
77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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