Document Detail


Application of proton magnetic resonance spectroscopy and computerized tomography in the diagnosis and treatment of nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  18563327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to investigate the application of proton magnetic resonance spectroscopy ((1)H-MRS) and computerized tomography (CT) in the quantitative diagnosis of nonalcoholic fatty liver disease (NAFLD) and evaluation of therapeutic effects, 22 patients with NAFLD were selected according to the Chinese Medical Association's (CMA) standard of the NAFLD in comparison with 20 healthy volunteers (as control group). Blood samples for biochemistry were collected. The severity of hepatosteatosis was evaluated by (1)H-MRS scan and CT scan of liver. The intrahepatic content of lipid (IHCL) and CT value ratio of liver to spleen were calculated. The patients in NAFLD group were treated with Ganzhixiao Capsule for 8 weeks. The changes in IHCL and CT value ratio of liver to spleen were observed before and after treatment. In NAFLD group serum ALT, TG, IHCL calculated by (1)HMRS were increased and CT value ratio of liver to spleen decreased significantly as compared with control group. After treatment for 8 weeks serum ALT, TG, IHCL were decreased significantly, while CT value ratio of liver to spleen increased significantly in NAFLD group. It was suggested that IHCL could be measured precisely by (1)HMRS. NAFLD was treated effectively by Ganzhixiao capsule.
Authors:
Nan Wang; Hui Dong; Shichao Wei; Fuer Lu
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Publication Detail:
Type:  Journal Article     Date:  2008-06-19
Journal Detail:
Title:  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban     Volume:  28     ISSN:  1672-0733     ISO Abbreviation:  J. Huazhong Univ. Sci. Technol. Med. Sci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-19     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169627     Medline TA:  J Huazhong Univ Sci Technolog Med Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  295-8     Citation Subset:  IM    
Affiliation:
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. southernl@sohu.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Fatty Liver / diagnosis*,  pathology*,  therapy*
Female
Humans
Lipids / chemistry
Liver / metabolism,  pathology,  radiography*
Magnetic Resonance Imaging / methods
Magnetic Resonance Spectroscopy
Male
Protons
Spectrum Analysis / methods
Spleen / metabolism
Tomography, X-Ray Computed / methods*
Chemical
Reg. No./Substance:
0/Lipids; 0/Protons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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