Document Detail

Application of prebiotics in infant foods.
MedLine Citation:
PMID:  15877896     Owner:  NLM     Status:  MEDLINE    
The rationale for supplementing an infant formula with prebiotics is to obtain a bifidogenic effect and the implied advantages of a 'breast-fed-like' flora. So far, the bifidogenic effect of oligofructose and inulin has been demonstrated in animals and in adults, of oligofructose in infants and toddlers and of a long-chain inulin (10 %) and galactooligosaccharide (90 %) mixture in term and preterm infants. The addition of prebiotics to infant formula softens stools but other putative effects remain to be demonstrated. Studies published post marketing show that infants fed a long-chain inulin/galactooligosaccharide mixture (0.8 g/dl) in formula grow normally and have no side-effects. The addition of the same mixture at a concentration of 0.8 g/dl to infant formula was therefore recognized as safe by the European Commission in 2001 but follow-up studies were recommended. It is thought that a bifidogenic effect is beneficial for the infant host. The rising incidence in allergy during the first year of life may justify the attempts to modulate the infant's flora. Comfort issues should not be confused with morbidity and are likely to be multifactorial. The functional effects of prebiotics on infant health need further study in controlled intervention trials.
Gigi Veereman-Wauters
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of nutrition     Volume:  93 Suppl 1     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  S57-60     Citation Subset:  IM    
Queen Paola Children's Hospital, ZNA, Antwerp, Belgium.
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MeSH Terms
Breast Feeding
Dietary Fiber / administration & dosage*
Infant Food*
Infant, Newborn
Infant, Premature
Intestinal Mucosa / immunology,  microbiology
Inulin / administration & dosage*
Oligosaccharides / administration & dosage*
Probiotics / administration & dosage
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Oligosaccharides; 0/oligofructose; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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