| Application of the polymerase chain reaction to the diagnosis and management of neonatal herpes simplex virus disease. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. | |
| | |
MedLine Citation:
|
PMID: 8940204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cerebrospinal fluid (CSF) specimens from 77 neonates with herpes simplex virus (HSV) disease were evaluated retrospectively by polymerase chain reaction (PCR). Samples were collected from 202 infants enrolled in a National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group trial that compared vidarabine with acyclovir for the treatment of neonatal HSV infection. HSV DNA was detected in the CSF of 26 (76%) of 34 infants with CNS disease, in 13 (93%) of 14 infants with disseminated infection, and in 7 (24%) of 29 with skin, eye, or mouth (SEM) involvement. One of the 7 PCR-positive SEM patients subsequently developed severe neurologic impairment. Eighteen (95%) of 19 infants with positive CSF PCR results after the completion of 10 days of antiviral therapy experienced significant morbidity or mortality. Application of PCR to neonatal HSV disease may provide additional information on which clinical decisions may be based, although its diagnostic utility outside the research setting is unproven. |
| | |
Authors:
|
D W Kimberlin; F D Lakeman; A M Arvin; C G Prober; L Corey; D A Powell; S K Burchett; R F Jacobs; S E Starr; R J Whitley |
Related Documents
:
|
21262044 - Enhancing infant attachment security: an examination of treatment efficacy and differen... 1727964 - Chronic chlamydia trachomatis infections in infants. 1168894 - Nosocomial influenza infection as a cause of intercurrent fevers in infants. 21892344 - Maintaining optimal oxygen saturation in premature infants. 4015144 - Congenital dislocation of the hip: early and late diagnosis and management compared. 9545014 - Presence of thyrotropin receptor in infant adipocytes. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: 174 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-01-08 Completed Date: 1997-01-08 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1162-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain
/
virology DNA, Viral / isolation & purification* Disease Progression Eye / virology Herpes Simplex / cerebrospinal fluid, diagnosis*, virology* Humans Infant, Newborn Mouth / virology Polymerase Chain Reaction Prognosis Retrospective Studies Simplexvirus / isolation & purification* Skin / virology |
| Grant Support | |
ID/Acronym/Agency:
|
AI-15113/AI/NIAID NIH HHS; AI-62554/AI/NIAID NIH HHS; RR-032/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human cytomegalovirus induces an Fc gamma receptor (Fc gammaR) in endothelial cells and fibroblasts ...
Next Document: MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in p...