Document Detail

Application of the polymerase chain reaction to the diagnosis and management of neonatal herpes simplex virus disease. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group.
MedLine Citation:
PMID:  8940204     Owner:  NLM     Status:  MEDLINE    
Cerebrospinal fluid (CSF) specimens from 77 neonates with herpes simplex virus (HSV) disease were evaluated retrospectively by polymerase chain reaction (PCR). Samples were collected from 202 infants enrolled in a National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group trial that compared vidarabine with acyclovir for the treatment of neonatal HSV infection. HSV DNA was detected in the CSF of 26 (76%) of 34 infants with CNS disease, in 13 (93%) of 14 infants with disseminated infection, and in 7 (24%) of 29 with skin, eye, or mouth (SEM) involvement. One of the 7 PCR-positive SEM patients subsequently developed severe neurologic impairment. Eighteen (95%) of 19 infants with positive CSF PCR results after the completion of 10 days of antiviral therapy experienced significant morbidity or mortality. Application of PCR to neonatal HSV disease may provide additional information on which clinical decisions may be based, although its diagnostic utility outside the research setting is unproven.
D W Kimberlin; F D Lakeman; A M Arvin; C G Prober; L Corey; D A Powell; S K Burchett; R F Jacobs; S E Starr; R J Whitley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  174     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-08     Completed Date:  1997-01-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1162-7     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA.
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MeSH Terms
Brain / virology
DNA, Viral / isolation & purification*
Disease Progression
Eye / virology
Herpes Simplex / cerebrospinal fluid,  diagnosis*,  virology*
Infant, Newborn
Mouth / virology
Polymerase Chain Reaction
Retrospective Studies
Simplexvirus / isolation & purification*
Skin / virology
Grant Support
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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