Document Detail

Application of poly-L-lactic acid nanosheet as a material for wound dressing.
MedLine Citation:
PMID:  23357985     Owner:  NLM     Status:  MEDLINE    
The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing.
Shimpo Aoki; Manabu Kinoshita; Hiromi Miyazaki; Akihiro Saito; Toshinori Fujie; Keiichi Iwaya; Shinji Takeoka; Daizoh Saitoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  131     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-04-01     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  236-40     Citation Subset:  AIM; IM    
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MeSH Terms
Lactic Acid*
Mice, Inbred C57BL
Wound Healing*
Reg. No./Substance:
0/Polymers; 26100-51-6/poly(lactic acid); 33X04XA5AT/Lactic Acid

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