| Application of poly-L-lactic Acid nanosheet as a material for wound dressing. | |
| | |
MedLine Citation:
|
PMID: 23357985 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
SUMMARY:: The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing. |
| | |
Authors:
|
Shimpo Aoki; Manabu Kinoshita; Hiromi Miyazaki; Akihiro Saito; Toshinori Fujie; Keiichi Iwaya; Shinji Takeoka; Daizoh Saitoh |
Related Documents
:
|
3104025 - Results of in vivo and in vitro studies for assessing prenatal toxicity. 21718065 - Quaternary alpha,alpha-2-oxoazepane alpha-amino acids: synthesis from ornithine-derived... 9261925 - Stereoselective dysmorphogenicity of the enantiomers of the valproic acid analogue 2-n-... 20307625 - Valproic acid stimulates clusterin expression in human astrocytes: implications for alz... 18560525 - Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. 17256895 - Effects of hydrogen-bonding and stacking interactions with amino acids on the acidity o... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Plastic and reconstructive surgery Volume: 131 ISSN: 1529-4242 ISO Abbreviation: Plast. Reconstr. Surg. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1306050 Medline TA: Plast Reconstr Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 236-40 Citation Subset: AIM; IM |
Affiliation:
|
Tokyo and Tokorozawa, Japan From the Clinic of Ichigaya, Ministry of Defense; the Departments of Immunology and Microbiology and Basic Pathology, and the Division of Traumatology, Research Institute, National Defense Medical College; and the Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bacteriophage Therapy for Staphylococcus aureus Biofilm-Infected Wounds: A New Approach to Chronic ...
Next Document: Surface Anatomy of the Middle Division of the Facial Nerve: Zuker's Point.