Document Detail

Application of partially fluorinated carboxylic acids as ion-pairing reagents in LC/ESI-MS.
MedLine Citation:
PMID:  24913879     Owner:  NLM     Status:  In-Data-Review    
This report describes the application of partially fluorinated carboxylic acids as ion-pairing reagents for basic analytes in high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (LC/ESI-MS) in positive-ion mode. Partially fluoridated carboxylic acids such as difluoroacetic acid, 3,3,3-trifluoropropionic acid and 3,3,3-trifluoromethyl-2-trifluoromethylpropionic acid functioned as volatile paired-ion similarly as trifluoroacetic acid (TFA). These acids provided basic analytes larger retention factor (k) compared to acetic acid or formic acid in LC. The ESI-MS signal strength of analytes with these acids were higher than that of TFA and was analogous to that of acetic acid or formic acid. The performances of partially fluorinated carboxylic acids in LC and ESI-MS for basic analytes were analyzed by multivariate statistical analysis using physicochemical descriptors of acids. Equations obtained in the analysis enabled us the quantitative evaluation of the performance of fluorinated carboxylic acids as ion-pair reagents for basic analytes in LC/ESI-MS.
Eiichi Yamamoto; Yasushi Ishihama; Naoki Asakawa
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Publication Detail:
Type:  Journal Article     Date:  2014-04-19
Journal Detail:
Title:  Talanta     Volume:  127     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-06-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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