Document Detail

Application of papaya latex-induced rat paw inflammation: model for evaluation of slowly acting antiarthritic drugs.
MedLine Citation:
PMID:  8032100     Owner:  NLM     Status:  MEDLINE    
Papaya latex-induced rat paw inflammation model for evaluating antiinflammatory activity has been developed and reported earlier. A number of drugs viz. aspirin, indomethacin, piroxicam, ibuprofen, prednisolone, levamisole, chloroquine, and boswellic acids showed antiinflammatory activity in this model. As the last three drugs showing the activity belonged to the group of slowly acting antiarthritic drugs, this present study was undertaken to study in detail the sensitivity of this model for slowly acting, clinically effective, antiarthritic drugs viz. chloroquine, levamisole, penicillamine, aurothioglucose, cyclophosphamide, and boswellic acids. These drugs are known to show no appreciable activity in the known models of inflammation and arthritis. All these drugs tested in three graded doses showed dose-related significant antiinflammatory activity in this model, whereas those drugs in the carrageenan model tested in similar doses showed insignificant activity. Aspirin employed as a reference standard showed significant activity in both the models. Thus the slowly acting antiarthritic drugs will be identified as those displaying significant activity in the papaya latex model and insignificant activity in the carrageenan model and to be aspirin-like by their significant activity in both the above models of inflammation.
O P Gupta; N Sharma; D Chand
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacological and toxicological methods     Volume:  31     ISSN:  1056-8719     ISO Abbreviation:  J Pharmacol Toxicol Methods     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-17     Completed Date:  1994-08-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9206091     Medline TA:  J Pharmacol Toxicol Methods     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Department of Pharmacology, Regional Research Laboratory, Jammu-Tawi, India.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Arthritis / drug therapy*
Disease Models, Animal*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Latex

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