Document Detail


Application of oxidants to the spectrophotometric determination of amlodipine besylate in pharmaceutical formulations.
MedLine Citation:
PMID:  15544797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three new spectrophotometric methods for the determination of amlodipine besylate have been proposed. The first two methods, i.e. A and B, are based on the oxidation of the drug with Fe(III) and the estimation of Fe(II) produced after chelation with either 1,10-phenanthroline or 2,2'-bipyridyl at 500 and 515 nm, respectively. The Beer's law was obeyed in the concentration ranges of 2-10 and 4-14 microg ml(-1) with molar absorptivity of 2.9 x 10(4) and 2.7 x 10(4) l mol(-1) cm(-1) for methods A and B, respectively. The third procedure depends on the interaction of amlodipine besylate with ammonium heptamolybdate tetrahydrate, which resulted in the formation of molybdenum blue (lambda(max) 825 nm). The linear dynamic range and the molar absorptivity values were found to be 15-59 microg ml(-1) and 1.8 x 10(4) l mol(-1) cm(-1), respectively. The results of the proposed procedures were validated statistically and compared with those obtained by the reference method. The proposed methods were applied successfully to the determination of amlodipine besylate in commercial tablets.
Authors:
Nafisur Rahman; Manisha Singh; Md Nasrul Hoda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  59     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-16     Completed Date:  2006-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  913-9     Citation Subset:  IM    
Affiliation:
Analytical Research Division, Department of Chemistry, Aligarh Muslim University, Aligarh, 202002 UP, India. cht17nr_amu@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Amlodipine / analysis*,  chemistry
Calcium Channel Blockers / analysis*,  chemistry
Coloring Agents
Ferric Compounds / chemistry
Indicators and Reagents
Molybdenum
Oxidants / chemistry
Oxidation-Reduction
Spectrophotometry / methods
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Coloring Agents; 0/Ferric Compounds; 0/Indicators and Reagents; 0/Oxidants; 11098-84-3/ammonium molybdate; 7439-98-7/Molybdenum; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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