Document Detail

Application of a new bioassay technique using goldfish for assessment of water toxicity.
MedLine Citation:
PMID:  18344213     Owner:  NLM     Status:  MEDLINE    
There are a variety of chemicals in aquatic environment, so it is important to assess the toxicity. The biomarkers such as induction of DNA damage, micronuclei, vitellogenin, and hepatic P450 in fish are known to be effective for monitoring genotoxic and/or estrogenic chemicals. However, there is little study to use these biomarkers in same fish. Goldfish (Carassius auratus) is widely used and is suitable in size to collect blood or organs. In this study, validity of multiple-biomarkers in goldfish was checked using standard chemicals and applied in the river water. Ho River, which flows through the textile dyeing factory in Shizuoka Prefecture, Japan, was reported to show genotoxicity toward Salmonella typhimurium TA98 and YG1024. When the goldfish were exposed to Ho River, DNA damage, estrogenic activity, and CYP1A induction were observed. Through the study, it was assumed that not only mutagens/carcinogens but also endocrine disrupting chemicals and poly aromatic hydrocarbons were present in Ho River. Therefore, chemical identification should be required. We could evaluate both genotoxicity and estrogenic activity simultaneously, so goldfish might be a good experimental model for estimation of chemical contamination levels in aquatic environment.
Yuya Deguchi; Nan Xiang Wu; Tomoyasu Toyoizumi; Shuichi Masuda; Hiroaki Nagaoka; Tetsushi Watanabe; Yukari Totsuka; Keiji Wakabayashi; Naohide Kinae
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental toxicology     Volume:  23     ISSN:  1522-7278     ISO Abbreviation:  Environ. Toxicol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100885357     Medline TA:  Environ Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-7     Citation Subset:  IM    
Copyright Information:
2008 Wiley Periodicals, Inc.
Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
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MeSH Terms
Biological Assay / methods*
Carcinogenicity Tests
Coloring Agents / metabolism,  toxicity
Cytochrome P-450 CYP1A1 / metabolism
DNA Damage / drug effects
Endocrine Disruptors / metabolism,  toxicity
Estrogens / metabolism
Fresh Water
Goldfish / metabolism*
Industrial Waste
Mutagenicity Tests
Polycyclic Hydrocarbons, Aromatic / metabolism,  toxicity
Risk Assessment
Textile Industry
Toxicity Tests / methods*
Water Pollutants, Chemical / metabolism,  toxicity*
Reg. No./Substance:
0/Coloring Agents; 0/Endocrine Disruptors; 0/Estrogens; 0/Industrial Waste; 0/Polycyclic Hydrocarbons, Aromatic; 0/Water Pollutants, Chemical; EC P-450 CYP1A1

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