Document Detail


Application of neurobehavioral toxicology methods to the military deployment toxicology assessment program.
MedLine Citation:
PMID:  10711393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The military Tri-Service (Army, Navy & Marines, Air Force) Deployment Toxicology Assessment Program (DTAP) represents a 30-year (1996-2026) planning effort to implement comprehensive systems for the protection of internationally deployed troops against toxicant exposures. A major objective of DTAP is the implementation of a global surveillance system to identify chemicals with the potential to reduce human performance capacity. Implementation requires prior development of complex human risk assessment models, known collectively as the Neurobehavioral Toxicity Evaluation Instrument (NTEI), based on mathematical interpolation of results from tissue-based and in vivo animal studies validated by human performance assessment research. The Neurobehavioral Toxicity Assessment Group (NTAG) at the Naval Health Research Center Detachment-Toxicology (NHRC-TD), Dayton, OH, and associated academic institutions are developing and cross-validating cellular-level (NTAS), laboratory small animal (NTAB), nonhuman primate (GASP), and human-based (GASH) toxicity assessment batteries. These batteries will be utilized to develop and evaluate mathematical predictors of human neurobehavioral toxicity, as a function of laboratory performance deficits predicted by quantitative structural analysis relationship (QSAR-like) properties of potential toxicants identified by international surveillance systems. Finally, physiologically-based pharmacokinetic (PBPK) and pharmacodynamic (PBPD) modeling of NTAS, NTAB, GASP, GASH data will support multi-organizational development and validation of the NTEI. The validated NTEI tool will represent a complex database management system, integrating global satellite surveillance input to provide real-time decision-making support for deployed military personnel.
Authors:
J Rossi; G D Ritchie; A F Nordholm; P L Knechtges; C L Wilson; J Lin; W K Alexander; K R Still
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  23     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-29     Completed Date:  2000-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-38     Citation Subset:  IM    
Affiliation:
Naval Health Research Center Detachment-Toxicology (NHRC-TD), Wright-Patterson Air Force Base (WPAFB), OH 45433, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*,  physiology
Cells, Cultured
Disease Models, Animal
Female
Hazardous Substances / pharmacokinetics,  poisoning*
Humans
Male
Military Personnel
Nervous System / drug effects*,  physiopathology
Neuropsychological Tests*
Planning Techniques
Risk Assessment
Toxicity Tests
Chemical
Reg. No./Substance:
0/Hazardous Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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