Document Detail


Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: furan (CAS No. 110-00-9).
MedLine Citation:
PMID:  20113857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Furan is commonly found in foods such as coffee, canned and jarred foods, including baby food containing meat, and various vegetables. It is thought to be formed by the thermal decomposition of carbohydrates. Furan is carcinogenic in rodents, although the detailed mechanism of action has not been completely established, for all the tumour types induced. Dose-response modelling of the data for hepatocellular tumours gives a BMDL10 of 1.23 mg/kg/day, and MOEs of between 750 and 4300 for exposures of infants and adults.
Authors:
Philip Carthew; Michael DiNovi; R Woodrow Setzer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48 Suppl 1     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S69-74     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ILSI Europe. Published by Elsevier Ltd.. All rights reserved.
Affiliation:
Unilever Research, UK. publications@ilsieurope.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / toxicity*
Data Interpretation, Statistical
Diet
Dose-Response Relationship, Drug
Female
Food Contamination / analysis*
Furans / toxicity*
Humans
Male
Mice
Models, Statistical
Mutagens / toxicity*
Rats
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Furans; 0/Mutagens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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