Document Detail


Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: (CAS No. 96-23-1) 1,3-dichloro-2-propanol (DCP).
MedLine Citation:
PMID:  20113855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1,3-Dichloro-2-propanol (DCP) is formed in foods under a variety of conditions. It was positive in a variety of in vitro genotoxicity tests, but was negative in two in vivo studies. DCP produced neoplasms at several sites in rats. Kidney tumours in male rats were selected as the critical tumour type. Dose-response modelling of the data for DCP gave a BMDL(10) for combined kidney carcinomas and adenomas in male rats of 9.62 mg/kg-body weight (bw)/day. The exposure of humans was estimated at an average of 0.00009 mg/kg-bw/day and a high exposure of 0.000136 mg/kg-bw/day. The MOEs for these exposures were 100,000 and 70,000, respectively.
Authors:
Gary Williams; Jean-Charles Leblanc; R Woodrow Setzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48 Suppl 1     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S57-62     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ILSI Europe. Published by Elsevier Ltd.. All rights reserved.
Affiliation:
New York Medical College, USA. publications@ilsieurope.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / toxicity*
Data Interpretation, Statistical
Diet
Dose-Response Relationship, Drug
Female
Food Contamination / analysis*
Humans
Male
Models, Statistical
Mutagens / toxicity*
Neoplasms / chemically induced
Rats
alpha-Chlorohydrin / analogs & derivatives*,  toxicity
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Mutagens; 96-23-1/1,3-dichloro-2-propanol; 96-24-2/alpha-Chlorohydrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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