Document Detail

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE 12: Sudan I (CAS No. 842-07-9).
MedLine Citation:
PMID:  20113850     Owner:  NLM     Status:  MEDLINE    
Sudan I is generally considered mutagenic based on various in vitro and in vivo tests and is carcinogenic in the rat. Dose-response modelling of the data for hepatocellular adenomas in male rats gave a BMDL(10) of 7.3mg/kg-bw/day. Sudan I is an unauthorised substance that might be present in food intermittently. The great variability and uncertainties in the human exposure data which are country specific, depending on consumption patterns and methodology used, resulted in a large range of MOE values (from 30 to 2,000,000).
Myriam Coulet; Jean-Charles Leblanc; R Woodrow Setzer
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48 Suppl 1     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S106-11     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ILSI Europe. Published by Elsevier Ltd.. All rights reserved.
Nestl? Research Centre, Switzerland.
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MeSH Terms
Carcinogens / toxicity*
Coloring Agents / toxicity*
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Food Contamination / analysis*
Models, Statistical
Mutagens / toxicity*
Naphthols / toxicity*
Neoplasms / chemically induced,  epidemiology
Reg. No./Substance:
0/Carcinogens; 0/Coloring Agents; 0/Mutagens; 0/Naphthols; 842-07-9/1-phenylazo-2-naphthol

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