Document Detail


Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: leucomalachite green.
MedLine Citation:
PMID:  19786059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leucomalachite green (LMG) is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for hepatocellular adenomas and carcinomas in female mice gave a BMDL10 of 20 mg/kg-bw/day. Limited data are available on the concentrations present in fish for human consumption. Human exposure estimates assumed that all consumed fish is contaminated with LMG. The calculated MoEs were 4,000,000 and 400,000 respectively for average and high exposure estimates.
Authors:
Andrew Renwick; Jean-Charles Leblanc; R Woodrow Setzer
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-26
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48 Suppl 1     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S75-80     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ILSI Europe. Published by Elsevier Ltd.. All rights reserved.
Affiliation:
University of Southampton, UK. publications@ilsieurope.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Antifungal Agents / toxicity*
Australia
Carcinogens / toxicity*
Data Interpretation, Statistical
Diet
Dose-Response Relationship, Drug
Europe
Female
Fishes / physiology*
Food Contamination / analysis*
Humans
Male
Meat / analysis*
Mice
Models, Statistical
Mutagens / toxicity*
Rats
Rosaniline Dyes / toxicity*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Carcinogens; 0/Mutagens; 0/Rosaniline Dyes; 129-73-7/leucomalachite green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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