| Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: leucomalachite green. | |
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MedLine Citation:
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PMID: 19786059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leucomalachite green (LMG) is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for hepatocellular adenomas and carcinomas in female mice gave a BMDL10 of 20 mg/kg-bw/day. Limited data are available on the concentrations present in fish for human consumption. Human exposure estimates assumed that all consumed fish is contaminated with LMG. The calculated MoEs were 4,000,000 and 400,000 respectively for average and high exposure estimates. |
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Authors:
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Andrew Renwick; Jean-Charles Leblanc; R Woodrow Setzer |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-09-26 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 Suppl 1 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: S75-80 Citation Subset: IM |
Copyright Information:
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Copyright 2009 ILSI Europe. Published by Elsevier Ltd.. All rights reserved. |
Affiliation:
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University of Southampton, UK. publications@ilsieurope.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antifungal Agents / toxicity* Australia Carcinogens / toxicity* Data Interpretation, Statistical Diet Dose-Response Relationship, Drug Europe Female Fishes / physiology* Food Contamination / analysis* Humans Male Meat / analysis* Mice Models, Statistical Mutagens / toxicity* Rats Rosaniline Dyes / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Carcinogens; 0/Mutagens; 0/Rosaniline Dyes; 129-73-7/leucomalachite green |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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