Document Detail


Application of high-performance liquid chromatography hyphenated techniques for identification of degradation products of cefpodoxime proxetil.
MedLine Citation:
PMID:  16846608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Application of the HPLC hyphenated techniques of LC-MS, LC-NMR and solvent-elimination LC-IR was demonstrated by the identification of the degradation products of a third generation cephalosporin antibiotic, cefpodoxime proxetil, in solid state, drug formulation and solution. Molecular weight and fragment information were obtained by LC-MS, and detailed structural information was confirmed by LC-NMR. Information on the carboxyl functional group obtained by solvent-elimination LC-IR was useful for confirmation of the ester hydrolysis. The degradation products were successfully identified without complicated isolation or purification processes.
Authors:
Naoto Fukutsu; Takao Kawasaki; Koichi Saito; Hiroyuki Nakazawa
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Publication Detail:
Type:  Journal Article     Date:  2006-07-18
Journal Detail:
Title:  Journal of chromatography. A     Volume:  1129     ISSN:  0021-9673     ISO Abbreviation:  J Chromatogr A     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-18     Completed Date:  2006-11-22     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
Affiliation:
Analytical and Quality Evaluation Research Laboratories, Sankyo Co Ltd, 1-12-1 Shinomiya, Hiratsuka-shi, Kanagawa, Japan. fukutu@sankyo.co.jp
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MeSH Terms
Descriptor/Qualifier:
Ceftizoxime / analogs & derivatives*,  analysis,  chemistry
Chromatography, High Pressure Liquid / methods*
Drug Stability
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy / methods
Molecular Structure
Reproducibility of Results
Spectrometry, Mass, Electrospray Ionization / methods
Spectrophotometry, Infrared / methods
Temperature
Chemical
Reg. No./Substance:
68401-81-0/Ceftizoxime; 87239-81-4/cefpodoxime proxetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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