Document Detail

Application of high-intensity focused ultrasound for the treatment of vascular anomalies: an experimental study in a cockscomb model.
MedLine Citation:
PMID:  18855312     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the efficacy and safety of high-intensity focused ultrasound (HIFU) treatment in an animal model of vascular anomalies together with the energy efficiency relationship after varying exposure times and energy levels. MATERIALS AND METHODS: Hainanhui cockscombs were irradiated using a CZP therapeutic apparatus with an optimal focus over different time periods. The changes in cuticular tissue of the cockscombs and the vascular regions were analyzed by TTC dye, H & E staining, light microscopy, and Doppler ultrasound. The rectal temperatures, weight, water and food consumption of the cocks were also measured during the whole experiment. RESULTS: H&E staining of the tissues and combs demonstrated similar histological findings, including vessel content, and thickness of the cuticular layers (ds). There were appreciable changes to the cockscombs after doses of 2.6 w x 200 s and 3.6 w x 120 s of HIFU exposure, with 100 % effectiveness and 0.00 % and 37.50 % irreversible damage, respectively. There were no differences with regard to water consumption, weight, rectal temperature and foraging levels monitored pre- and post-HIFU administration of the two doses. CONCLUSIONS: HIFU exposure is effective in destroying the vascular targeted anomaly with no skin burns, bleeding, large vessel ruptures or other complications. HIFU is feasible, noninvasive and safe for the treatment of vascular anomalies, but clinical trials are necessary.
S Wang; J Zhang; C Li; X Jin; C Guo; Z Wang
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-14
Journal Detail:
Title:  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie     Volume:  18     ISSN:  0939-7248     ISO Abbreviation:  Eur J Pediatr Surg     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105263     Medline TA:  Eur J Pediatr Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  328-33     Citation Subset:  IM    
Department of Pediatric Oncology Surgery, The Children's Hospital of Chongqing Medical University, Chongqing, China.
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MeSH Terms
Blood Flow Velocity
Blood Vessels / physiopathology,  ultrastructure
Comb and Wattles / blood supply*
Microscopy, Electron, Transmission
Treatment Outcome
Ultrasonic Therapy / methods*
Ultrasonography, Doppler
Vascular Malformations / pathology,  therapy*,  ultrasonography

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