| Application of genomics in the prevention, treatment and management of Achilles tendinopathy and anterior cruciate ligament ruptures. | |
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MedLine Citation:
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PMID: 22762739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Musculoskeletal soft tissue injuries such as Achilles tendinopathy and anterior cruciate ligament ruptures are common among elite athletes, recreational athletes and physically active individuals. The consequences of injury may be devastating and prevent the recreational or competitive athlete from reaching their potential or lead to a premature end to their careers. Although these injuries have been well described at a clinical level, the biological mechanisms causing these injuries are poorly understood. A further understanding of the biological mechanisms underlying the injury will assist the treatment and management of these injuries. In addition, understanding the biology is an important prerequisite in developing models that can be used to effectively identify risk, as well as, implement personalised prevention, treatment and rehabilitation programmes. Both intrinsic, including genetic variants, and extrinsic risk factors have nevertheless been implicated in the aetiology of these injuries. To date, several patents have been filed which involve the use of specific polymorphisms and regions within specific genes to be used in a genetic test for either tendon or ligament injury risk. The objective of this manuscript will be to review the evidence for the genetic predisposition to soft tissue injury, as well as the application of this data in the prevention, treatment and management of musculoskeletal soft tissue injuries. |
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Authors:
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A V September; M Posthumus; M Collins |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-04 |
Journal Detail:
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Title: Recent patents on DNA & gene sequences Volume: - ISSN: 2212-3431 ISO Abbreviation: Recent Pat DNA Gene Seq Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101299745 Medline TA: Recent Pat DNA Gene Seq Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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UCT/MRC Research Unit for Exercise Science and Sports Medicine P.O. Box 115, Newlands 7725, South Africa. malcolm.collins@uct.ac.za. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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