Document Detail

Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MS(E) data collection technique.
MedLine Citation:
PMID:  23020077     Owner:  NLM     Status:  Publisher    
Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MS(E) data collection mode was developed as a very effective biochemical analytical tool for precise identification of important biomarkers in the adenine-induced CRF rats. Nine endogenous metabolites were identified by using metabonomic method combined with multivariate data analysis, the accurate mass, isotopic pattern, MS(E) fragments information and MassLynx i-FIT algorithm. The identified metabolites indicated the perturbations of bile acid and phospholipid metabolism are related to CRF rats. This work shows that metabonomics method is a valuable tool in CRF mechanism study.
Ying-Yong Zhao; Xian-Long Cheng; Feng Wei; Xu Bai; Rui-Chao Lin
Related Documents :
2272707 - Bioavailability of doxycycline from dissolved doxycycline hydrochloride tablets--compar...
6491967 - Quantitation of metronidazole in pharmaceutical dosage forms using high-performance liq...
24441017 - The use of multivariate curve resolution methods to improve the analysis of muramic aci...
23688297 - Glycomic analysis using glycoprotein immobilization for glycan extraction.
17306617 - Novel oxidative coupling reactions of cisapride or metaclopramide with phenoxazines and...
7980387 - An improved method for butyrylcholinesterase phenotyping.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  -     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, the College of Life Sciences, Northwest University , Xi'an, Shaanxi , PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nano-particulate non-viral agent for the effective delivery of pDNA and siRNA to differentiated cell...
Next Document:  Evidence for complex selection on four-fold degenerate sites in Drosophila melanogaster.