| Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MS(E) data collection technique. | |
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MedLine Citation:
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PMID: 23020077 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MS(E) data collection mode was developed as a very effective biochemical analytical tool for precise identification of important biomarkers in the adenine-induced CRF rats. Nine endogenous metabolites were identified by using metabonomic method combined with multivariate data analysis, the accurate mass, isotopic pattern, MS(E) fragments information and MassLynx i-FIT algorithm. The identified metabolites indicated the perturbations of bile acid and phospholipid metabolism are related to CRF rats. This work shows that metabonomics method is a valuable tool in CRF mechanism study. |
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Authors:
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Ying-Yong Zhao; Xian-Long Cheng; Feng Wei; Xu Bai; Rui-Chao Lin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-1 |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: - ISSN: 1366-5804 ISO Abbreviation: Biomarkers Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, the College of Life Sciences, Northwest University , Xi'an, Shaanxi , PR China. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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