Document Detail


Application of a drug delivery system to a steroidal ophthalmic preparation with lipid microspheres.
MedLine Citation:
PMID:  3504514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The applicability of a drug delivery system to an ophthalmic preparation was examined using lipid microspheres containing hydrocortisone 17-butyrate 21-propionate (HBP). A 3H-labelled HBP ophthalmic suspension and 3H-labelled HBP lipid microspheres were applied to rabbit eyes, which were then enucleated at fixed intervals to determine the level of 3H-labelled HBP in ocular tissues. The lipid microspheres were shown to deliver the drug to the anterior ocular tissues more effectively than the ophthalmic suspension. It is suggested that a lipid microsphere ophthalmic preparation of various lipophilic drugs including steroids may be useful as a drug delivery system for ophthalmic therapy.
Authors:
A Yanagawa; Y Mizushima; A Komatsu; M Horiuchi; E Shirasawa; R Igarashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of microencapsulation     Volume:  4     ISSN:  0265-2048     ISO Abbreviation:  J Microencapsul     Publication Date:    1987 Oct-Dec
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  8500513     Medline TA:  J Microencapsul     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-31     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, St Marianna University, School of Medicine, Kawasaki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Anti-Inflammatory Agents / administration & dosage*
Drug Carriers
Eye / metabolism
Hydrocortisone / administration & dosage,  analogs & derivatives*,  pharmacokinetics
Liposomes
Male
Microspheres
Ophthalmic Solutions
Rabbits
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Drug Carriers; 0/Liposomes; 0/Ophthalmic Solutions; 50-23-7/Hydrocortisone; 72590-77-3/hydrocortisone 17-butyrate 21-propionate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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