| Application of the cycloSal-prodrug approach for improving the biological potential of phosphorylated biomolecules. | |
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MedLine Citation:
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PMID: 16735066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pronucleotides represent a promising tool to improve the biological activity of nucleoside analogs in antiviral and cancer chemotherapy. The cycloSal-approach is one of several conceptually different pronucleotide systems. This approach can be applied to various nucleoside analogs. A salicyl alcohol as a cyclic bifunctional masking unit is used, and shown to afford a chemically driven release of the particular nucleotide from the lipophilic phosphate triester precursor molecule. A conceptual extension of the cycloSal-approach results in the design of "lock-in"-cycloSal-derivatives. The cycloSal-approach is not restricted to the delivery of bioactive nucleotides but also useful for the intracellular delivery of hexose-1-phosphates. |
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Authors:
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C Meier; J Balzarini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-05-09 |
Journal Detail:
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Title: Antiviral research Volume: 71 ISSN: 0166-3542 ISO Abbreviation: Antiviral Res. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-11-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109699 Medline TA: Antiviral Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 282-92 Citation Subset: IM |
Affiliation:
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Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany. chris.meier@chemie.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
/
chemical synthesis,
chemistry,
pharmacology* Cell Line Dideoxynucleotides Drug Design* HIV-1 / drug effects HIV-2 / drug effects Humans Nucleotides / chemistry*, pharmacology Prodrugs / chemistry*, pharmacology Salicylic Acids / chemistry*, pharmacology Stavudine / analogs & derivatives*, chemical synthesis, chemistry, pharmacology Structure-Activity Relationship Thymine Nucleotides |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate; 0/Dideoxynucleotides; 0/Nucleotides; 0/Prodrugs; 0/Salicylic Acids; 0/Thymine Nucleotides; 3056-17-5/Stavudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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