Document Detail

Application of current allergy assessment guidelines to next-generation biotechnology-derived crops.
MedLine Citation:
PMID:  17955998     Owner:  NLM     Status:  MEDLINE    
In any single day, our immune systems are exposed to thousands of different proteins from the environment and the food we eat. In a portion of the human population, some of those proteins will stimulate the immune systems to synthesize immunoglobulin E in an allergenic response. The discrepancy between the vast numbers of proteins we encounter and the limited number of proteins that actually become allergens have led scientists on a quest to discover what unique features exist that make proteins destined to be allergens. The information gained from these studies has led to an allergy assessment strategy that characterizes the potential allergenicity of biotechnology products prior to their commercialization. This testing strategy appears to be effective as shown by the fact that there have been no clinically documented food allergic reactions to any of the biotechnology proteins introduced into food crops, to date. The next generation of biotechnology products will most likely contain more complex traits, including nutritionally enhanced food crops, and the question arises as to whether the current allergy assessment strategy will be sufficient to protect the health of the consuming public. In this paper, we discuss general allergen characteristics in order to better understand how proteins become allergens, summarize the current allergy assessment process, evaluate the different aspects of this process for their adequacy in determining the allergenic potential of engineered functional foods, and, finally, we assess the possibility of new technologies having a positive impact on the allergy assessment of nutritionally enhanced crops.
Gary A Bannon; Susan Martino-Catt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of AOAC International     Volume:  90     ISSN:  1060-3271     ISO Abbreviation:  J AOAC Int     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-10-24     Completed Date:  2007-11-28     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9215446     Medline TA:  J AOAC Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1492-9     Citation Subset:  IM    
Monsanto Co., Global Regulatory Sciences, 800 N. Lindbergh Blvd, St. Louis, MO 63167, USA.
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MeSH Terms
Allergens / chemistry
Biotechnology / methods*,  trends
Computational Biology / methods
Crops, Agricultural / genetics*
Food Hypersensitivity / genetics
Food, Genetically Modified
Guidelines as Topic
Hypersensitivity / diagnosis*
Hypersensitivity, Immediate / genetics
Immunoglobulin E / metabolism
Plants, Genetically Modified
Proteins / analysis,  chemistry
Reg. No./Substance:
0/Allergens; 0/Proteins; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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