| Application of a convenient extraction procedure to analyze gamma-hydroxybutyric acid in fatalities involving gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol. | |
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MedLine Citation:
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PMID: 11599603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most common chemicals that can be ingested and lead to greater than endogenous levels of gamma-hydroxybutyric acid (GHB) in decedents are salts of GHB, gamma-butyrolactone (GBL), and 1,4-butanediol (BD). Results for three deaths involving the ingestion of one or another of these three chemicals, which led to findings of GHB in the decedents, are presented. An extraction procedure that facilitates the quantitation of GHB was developed. If present in the same specimen, both GHB and GBL can be quantitated. To determine the GBL concentration, the specimen is first analyzed for existing GHB, the GBL is then converted to GHB, and the analysis is repeated. The difference between the results in molarity units can yield the GBL concentration. A separate procedure was utilized for estimating concentrations of BD. Specimens analyzed included urine, blood, ocular fluid, brain, and solutions consumed by the decedents prior to death. The procedures were found to be convenient in as much as they are relatively rapid, precise, and economical. |
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Authors:
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W C Duer; K L Byers; J V Martin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 25 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-15 Completed Date: 2002-02-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 576-82 Citation Subset: IM |
Affiliation:
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Medical Examiner Department, Hillsborough County, Tampa, Florida, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Butyrolactone
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poisoning* Autopsy Butylene Glycols / poisoning* Chemistry Techniques, Analytical / methods Humans Hydroxybutyrates / analysis*, poisoning* Poisoning / diagnosis Solvents / poisoning* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Butylene Glycols; 0/Hydroxybutyrates; 0/Solvents; 110-63-4/1,4-butanediol; 591-81-1/4-hydroxybutyric acid; 96-48-0/4-Butyrolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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