Document Detail

Application of cerium chloride to improve the acid resistance of dentine.
MedLine Citation:
PMID:  20399417     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effect of cerium chloride, cerium chloride/fluoride and fluoride application on calcium release during erosion of treated dentine. METHODS: Forty dentine samples were prepared from human premolars and randomly assigned to four groups (1-4). Samples were treated twice a day for 5 days, 30s each, with the following solutions: group 1 placebo, group 2 fluoride (Elmex fluid), group 3 cerium chloride and group 4 combined fluoride and cerium chloride. For the determination of acid resistance, the samples were consecutively eroded six times for 5 min with lactic acid (pH 3.0) and the calcium release in the acid was determined. Furthermore, six additional samples per group were prepared and used for EDS analysis. SEM pictures of these samples of each group were also captured. RESULTS: Samples of group 1 presented the highest calcium release when compared with the samples of groups 2-4. The highest acid resistance was observed for group 2. Calcium release in group 3 was similar to that of group 4 for the first two erosive attacks, after which calcium release in group 4 was lower than that of group 3. Generally, the SEM pictures showed a surface coating for groups 2-4. No deposits were observed in group 1. CONCLUSION: Although fluoride showed the best protective effect, cerium chloride was also able to reduce the acid susceptibility of dentine significantly, which merits further investigation.
Florian J Wegehaupt; Beatrice Sener; Thomas Attin; Patrick R Schmidlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  55     ISSN:  1879-1506     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  D; IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zürich, Zürich, Switzerland.
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MeSH Terms
Calcium / analysis
Cariostatic Agents / pharmacology,  therapeutic use
Cerium / pharmacology,  therapeutic use*
Dentin / chemistry,  drug effects*,  ultrastructure
Diamines / pharmacology,  therapeutic use
Drug Combinations
Fluorides / pharmacology,  therapeutic use
Hydrogen-Ion Concentration
Lactic Acid / pharmacology
Microscopy, Electron, Scanning
Photoelectron Spectroscopy
Spectrophotometry, Atomic
Tooth Erosion / metabolism*,  prevention & control*
Reg. No./Substance:
0/Cariostatic Agents; 0/Diamines; 0/Drug Combinations; 0/Fluorides; 0/Olaflur; 50-21-5/Lactic Acid; 7440-45-1/Cerium; 7440-70-2/Calcium; 7790-86-5/cerous chloride

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