Document Detail


Application of cavitation promoting surfaces in management of acute ischemic stroke.
MedLine Citation:
PMID:  23141666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High frequency, low intensity ultrasound has the potential to accelerate the clearance of thrombotic occlusion in the absence of cavitation. At high frequency ultrasound, high acoustic pressures, >5.2MPa, are required to generate cavitation in thrombus. The focus of this study was to reduce the cavitation threshold by applying materials with appropriate nucleation sites at the transducer-thrombus boundary to further augment sonothrombolysis. Heterogeneous and homogenous nucleation sites were generated on the outer surface of a polyimide tube (PI) using microfringed (MPI) and laser induced (LPI) microcavities. The cavitation threshold of these materials was determined using a passive cavitation detection system. Furthermore, the biological impact of both materials was investigated in vitro. The results revealed that both MPI and LPI have the potential to induce cavitation at acoustic pressure levels as low as 2.3MPa. In the presence of cavitation, thrombolysis rate could be enhanced by up to two times without any evidence of hemolysis that is generally associated with cavitation activities in blood. A prototype ultrasonic catheter operating at 1.7MHz frequency and acoustic pressure of 2.3MPa with either of MPI or LPI could be considered as a viable option for treatment of acute ischemic stroke.
Authors:
Azita Soltani
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-22
Journal Detail:
Title:  Ultrasonics     Volume:  53     ISSN:  1874-9968     ISO Abbreviation:  Ultrasonics     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-01-24     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0050452     Medline TA:  Ultrasonics     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  580-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Hemolysis
Humans
Mechanical Thrombolysis
Stroke / therapy*
Ultrasonic Therapy / adverse effects,  methods*
Grant Support
ID/Acronym/Agency:
5R21NS058629-02/NS/NINDS NIH HHS; R21 NS058629/NS/NINDS NIH HHS
Comments/Corrections

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