Document Detail


Application of bromhexine metabolite VIII (NA 872) and bromhexine-glucose in treatment of adult respiratory distress syndrome; experimental and clinical results .
MedLine Citation:
PMID:  7414106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors study the changes in cardiopulmonary function after application of bromhexine metabolite VIII (NA 872) in an animal model of adult respiratory distress syndrome (ARDS) and bromhexine glucose solution (BGS) in ARDS patients. After damage of the lung alveolar surfactant by intratracheal atomization of 0.2 M HCl in LEWE Minipigs significant changes in lung compliance, dead space ventilation, venous admixture, alveolo-arterial oxygen tension difference, pulmonary vascular resistance, and oxygen uptake are present under application of NA 872 in comparison to untreated animals. In ARDS patients treated with BGS, pulmonary function is significantly ameliorated indicated by changes in static effective compliance, oxygen exchange ratio, and alveolo-arterial oxygen tension difference.
Authors:
W Kuckelt; R Dauberschmidt; J Scharfenberg; K Winsel; B Lachmann; H Frenzke; U Hieronymi; H Mrochen; M Meyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  39     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1980  
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  264-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bromhexine / analogs & derivatives,  therapeutic use*
Humans
Lung / physiopathology*
Lung Compliance / drug effects
Respiration
Respiratory Dead Space
Respiratory Distress Syndrome, Adult / drug therapy*,  physiopathology
Swine / physiology
Vascular Resistance
Ventilation-Perfusion Ratio
Chemical
Reg. No./Substance:
3572-43-8/Bromhexine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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