| Application of bromhexine metabolite VIII (NA 872) and bromhexine-glucose in treatment of adult respiratory distress syndrome; experimental and clinical results . | |
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MedLine Citation:
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PMID: 7414106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors study the changes in cardiopulmonary function after application of bromhexine metabolite VIII (NA 872) in an animal model of adult respiratory distress syndrome (ARDS) and bromhexine glucose solution (BGS) in ARDS patients. After damage of the lung alveolar surfactant by intratracheal atomization of 0.2 M HCl in LEWE Minipigs significant changes in lung compliance, dead space ventilation, venous admixture, alveolo-arterial oxygen tension difference, pulmonary vascular resistance, and oxygen uptake are present under application of NA 872 in comparison to untreated animals. In ARDS patients treated with BGS, pulmonary function is significantly ameliorated indicated by changes in static effective compliance, oxygen exchange ratio, and alveolo-arterial oxygen tension difference. |
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Authors:
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W Kuckelt; R Dauberschmidt; J Scharfenberg; K Winsel; B Lachmann; H Frenzke; U Hieronymi; H Mrochen; M Meyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respiration; international review of thoracic diseases Volume: 39 ISSN: 0025-7931 ISO Abbreviation: Respiration Publication Date: 1980 |
Date Detail:
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Created Date: 1980-11-24 Completed Date: 1980-11-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0137356 Medline TA: Respiration Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 264-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bromhexine / analogs & derivatives, therapeutic use* Humans Lung / physiopathology* Lung Compliance / drug effects Respiration Respiratory Dead Space Respiratory Distress Syndrome, Adult / drug therapy*, physiopathology Swine / physiology Vascular Resistance Ventilation-Perfusion Ratio |
| Chemical | |
Reg. No./Substance:
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3572-43-8/Bromhexine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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