| Application of breath-hold T2-weighted, first-pass perfusion and gadolinium-enhanced T1-weighted MR imaging for assessment of myocardial viability in a pig model. | |
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MedLine Citation:
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PMID: 10813856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to correlate the abnormal signal area on various magnetic resonance (MR) images to the infarct area on pathologic examination and to assess the myocardial viability on the basis of MR images. T2-weighted, first-pass perfusion, and delayed gadolinium-enhanced T1-weighted images were used as "one-stop examinations" in a pig model of reperfused myocardial infarction. The results of each MR image were compared with those of 2,3, 5-triphenyltetrazolium chloride (TTC) staining. The abnormal signal areas on T2-weighted and Gd-enhanced T1-weighted images were larger than the infarct areas on TTC staining (34.7% and 32.3% vs. 28.3%; P< 0.05), whereas the nonperfused areas on perfusion images were correlated (25.6% vs, 28.3%; P = 0.139). Electron microscopic examination showed severely distorted ultrastructures in the infarct areas and mildly damaged ultrastructures in the peri-infarct areas. Perfusion images probably reflected the infarct areas, whereas T2-weighted and Gd-enhanced T1-weighted images seemed to include peri-infarct as well as infarct areas. |
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Authors:
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S I Choi; C Z Jiang; K H Lim; S T Kim; C H Lim; G Y Gong; T H Lim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 11 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-05-31 Completed Date: 2000-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 476-80 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Wiley-Liss, Inc. |
Affiliation:
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Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 138-736, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coloring Agents Contrast Media* Electrocardiography Gadolinium DTPA / diagnostic use* Image Processing, Computer-Assisted Magnetic Resonance Imaging* / methods Myocardial Infarction / diagnosis*, pathology Myocardial Reperfusion Myocardium / pathology* Swine Tetrazolium Salts |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Contrast Media; 0/Tetrazolium Salts; 80529-93-7/Gadolinium DTPA; 902-00-1/triphenyltetrazolium |
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