Document Detail

Application of XANES profiles to X-ray spectromicroscopy for biomedical specimens: Part II. Mapping oxidation state of cysteine in human hair.
MedLine Citation:
PMID:  21876281     Owner:  NLM     Status:  In-Data-Review    
Human hair fibers are primarily composed of keratin protein, characterized by a very high content of cysteine, a sulfur-containing amino acid, which ordinarily forms cystine via a disulfide bond. It is known that some cystine residues are converted to cysteic acid during permanent waving or hair coloring, although details of their distribution and extent are still unclear. In this study, by using difference in XANES profiles of cystine and cysteic acid at the S-K absorption edge, the formation of cysteic acid was confirmed for homogenized samples of permed or bleached hair. Furthermore chemical mapping of cysteic acid was performed on hair-section samples with X-ray contact microscopy. The peripheral region, cuticle, in bleached hair showed the highest content of cysteic acid compared with the other parts, while permed hair showed relatively uniform distribution. This finding suggests that perming and bleaching damage hair by different mechanisms.
Takafumi Inoue; Kouji Takehara; Norio Shimizu; Yoshinori Kitajima; Kunio Shinohara; Atsushi Ito
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of X-ray science and technology     Volume:  19     ISSN:  1095-9114     ISO Abbreviation:  J Xray Sci Technol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000080     Medline TA:  J Xray Sci Technol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
Innovative Beauty Science Laboratory, Kanebo Cosmetics Inc., Kotobuki-cho, Odawara-shi, Kanagawa, Japan.
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