| Application of Prussian blue-based optical sensor in pharmaceutical analysis. | |
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MedLine Citation:
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PMID: 11451654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Optical flow-through cell-detector with incorporated transparent chemosensitive layer of Prussian blue has been applied in simple, single-channel flow-injection system for pharmaceutical analysis. The reductant analyte converts the Prussian blue based sensing layer to Prussian white form, and the attendant color change is used for sensing. Discoloration of the film is spectrophotometrically detected at 720 nm wavelength. The flow injection system has been successfully used for selective determination of ascorbic acid in simple and complex pharmaceuticals. The method is free from interferences caused by various ions and active ingredients commonly found in pharmaceuticals. The flow-through sensor is useful for spectrophotometric flow-injection analysis of intensively colored and turbid samples. The results of medicine analysis are comparable to those obtained using reference pharmacopeal method. The analytical system could be also used for determination of cysteine and hydrogen peroxide in medicines. |
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Authors:
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T Lenarczuk; S Głab; R Koncki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 26 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-13 Completed Date: 2001-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 163-9 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Warsaw, Pasteura 1, PL-02-093 Warsaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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analysis Cysteine / analysis Equipment Design Flow Injection Analysis / instrumentation*, methods Hydrogen Peroxide / analysis Pharmaceutical Preparations / analysis* Prussian Blue Reaction* Spectrophotometry / methods |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations; 50-81-7/Ascorbic Acid; 52-90-4/Cysteine; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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