| Application of Nickel(II) Complexes to the Efficient Synthesis of α- or β-Amino Acids. | |
| | |
MedLine Citation:
|
PMID: 22273373 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Nonproteinogenic α- or β-amino acids have attracted tremendous attention, as they are widely utilized for biological, biochemical, pharmaceutical, and asymmetric chemical investigations. Recently, we developed a series of new strategies for preparing achiral and chiral nickel(ii) complexes for the synthesis of amino acids. We applied these new methods utilizing chiral nickel(ii) complexes for the asymmetric Mannich reaction to synthesize enantiopure α,β-diamino acids, the enantioselective tandem conjugate addition-elimination reaction to prepare glutamic acid derivatives, the Suzuki coupling reaction to yield β(2)-amino acid derivatives, the asymmetric Mannich reaction to synthesize 3-aminoaspartate, the asymmetric Michael addition reaction to give β-substituted-α,γ-diaminobutyric acid derivatives, the asymmetric alkylation reaction to prepare linear ω-trifluoromethyl containing amino acids, and the asymmetric Michael addition reaction to synthesize syn-β-substituted tryptophans. |
| | |
Authors:
|
Jiang Wang; Lei Zhang; Hualiang Jiang; Kaixian Chen; Hong Liu |
Related Documents
:
|
14670733 - Structural and serological characterisation of the o-antigenic polysaccharide of the li... 11423143 - Pectic polysaccharide rhamnogalacturonan ii is covalently linked to homogalacturonan. 2284003 - Recombinant methionyl bovine prolactin: loss of bioactivity after single amino acid del... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chimia Volume: 65 ISSN: 0009-4293 ISO Abbreviation: Chimia (Aarau) Publication Date: 2011 |
Date Detail:
|
Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0373152 Medline TA: Chimia (Aarau) Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 919-24 Citation Subset: IM |
Affiliation:
|
Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cu((i))/Amino Acid Catalyzed Coupling Reactions of Aryl Halides and Nucleophiles: Applications in La...
Next Document: Active Methylene-based Multicomponent Reactions under Microwave Heating.