Document Detail

Application of Nickel(II) Complexes to the Efficient Synthesis of α- or β-Amino Acids.
MedLine Citation:
PMID:  22273373     Owner:  NLM     Status:  In-Data-Review    
Nonproteinogenic α- or β-amino acids have attracted tremendous attention, as they are widely utilized for biological, biochemical, pharmaceutical, and asymmetric chemical investigations. Recently, we developed a series of new strategies for preparing achiral and chiral nickel(ii) complexes for the synthesis of amino acids. We applied these new methods utilizing chiral nickel(ii) complexes for the asymmetric Mannich reaction to synthesize enantiopure α,β-diamino acids, the enantioselective tandem conjugate addition-elimination reaction to prepare glutamic acid derivatives, the Suzuki coupling reaction to yield β(2)-amino acid derivatives, the asymmetric Mannich reaction to synthesize 3-aminoaspartate, the asymmetric Michael addition reaction to give β-substituted-α,γ-diaminobutyric acid derivatives, the asymmetric alkylation reaction to prepare linear ω-trifluoromethyl containing amino acids, and the asymmetric Michael addition reaction to synthesize syn-β-substituted tryptophans.
Jiang Wang; Lei Zhang; Hualiang Jiang; Kaixian Chen; Hong Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chimia     Volume:  65     ISSN:  0009-4293     ISO Abbreviation:  Chimia (Aarau)     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373152     Medline TA:  Chimia (Aarau)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  919-24     Citation Subset:  IM    
Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai, China.
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