Document Detail


Application of the Neospora caninum IgG avidity ELISA in assessment of chronic reproductive losses after an outbreak of neosporosis in a herd of beef cattle.
MedLine Citation:
PMID:  12580287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Point-source infections are most likely the cause for Neospora caninum-induced abortion outbreaks in cattle, whereas an increased annual abortion rate may be a consequence of vertical transmission. The aims of the present study were to examine the reproductive effects of neosporosis in a beef herd for 3 years, after a point-source outbreak and to use IgG avidity serology to examine the chronicity of infections and patterns of transmission. During the study, 76-78% of animals were seropositive for N. caninum. The pregnancy rate varied from 88% to 94%, without any reduction in the pregnancy rate of seropositive cows compared with seronegative cows. The annual abortion rate was 2.5-5.5%, and all but 1 abortion occurred in seropositive dams. The efficiency of vertical transmission was estimated to be 85%. Several calves, born to seronegative dams, were seropositive at 6-13 months of age, indicating a 22% mean annual rate of horizontal transmission. The mean avidity in seropositive cows increased from 30 during the initial outbreak to 74 after 3 years. The mode of IgG avidity was 21-40 during the initial abortion outbreak, 41-60 after 1 year, and 61-80 after 2 and 3 years. The results reveal high annual rates of both vertical and horizontal transmission of N. caninum in a herd of beef cows and provide further validation on the ability of the N. caninum IgG avidity ELISA to accurately assess the chronicity of infection.
Authors:
Camilla Björkman; Milton M McAllister; Jenny Frössling; Katarina Näslund; Felicia Leung; Arvid Uggla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc     Volume:  15     ISSN:  1040-6387     ISO Abbreviation:  J. Vet. Diagn. Invest.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9011490     Medline TA:  J Vet Diagn Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  IM    
Affiliation:
Department of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, PO Box 7019, SE-750 07 Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Veterinary / complications,  immunology,  parasitology,  transmission
Animals
Antibody Affinity
Cattle
Cattle Diseases / epidemiology*,  immunology,  parasitology,  transmission*
Chronic Disease
Coccidiosis / complications,  epidemiology,  transmission*,  veterinary*
Disease Outbreaks / veterinary
Enzyme-Linked Immunosorbent Assay
Female
Immunoglobulin G / blood*
Neospora / immunology*
Pregnancy
Pregnancy Complications, Infectious / immunology,  parasitology,  veterinary*
Time Factors
Chemical
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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