| Application of Mie theory to determine the structure of spheroidal scatterers in biological materials. | |
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MedLine Citation:
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PMID: 17440576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present here the results of a numerical study on light scattering from nonspherical particles with relevance to detecting precancerous states in epithelial tissues. In previous studies of epithelial cell nuclei, the experimental light scattering data have been analyzed by comparison with Mie theory. However, given the spheroidal shape of many cell nuclei, the validity of this assumption demands a thorough investigation. We investigate this assumption by using the T-matrix method to model light scattered from spheroids with parameters relevant to epithelial cell nuclei. In our previous studies, we have developed a data analysis procedure that extracts the oscillatory component of the angular-scattering distribution for an ensemble of epithelial cell nuclei for comparison with Mie theory. We demonstrate that application of our analysis procedure to the predictions of the T-matrix method for spheroids, oriented such that their axis of symmetry is aligned with the incident light propagation direction, generally yields the spheroid dimension that is transverse to the incident light propagation direction with subwavelength accuracy. |
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Authors:
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Justin D Keener; Kevin J Chalut; John W Pyhtila; Adam Wax |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Optics letters Volume: 32 ISSN: 0146-9592 ISO Abbreviation: Opt Lett Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-18 Completed Date: 2007-06-14 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 1326-8 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus Shape / physiology* Cell Shape / physiology Epithelium / ultrastructure Humans Light* Models, Biological* Neoplasms / diagnosis*, pathology Scattering, Radiation* Spectrum Analysis |
| Grant Support | |
ID/Acronym/Agency:
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R33-CA109907/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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